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Issue 67, 2017, Issue in Progress
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Cucurbit[7]uril complexations of Good's buffers

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Abstract

The cucurbit[7]uril (CB[7]) host–guest complexations of a series of zwitterionic “Good's” biological pH buffers have been investigated in aqueous solution by means of 1H NMR spectroscopy. The cyclohexylammonium buffers bind very strongly (KCB[7] = 107 to 108 dm3 mol−1), while the morpholinium (102 to 103 dm3 mol−1) and piperazinium (103 to 104 dm3 mol−1) buffers have binding constants several orders of magnitude smaller. The binding constants increase as the distance between the ammonium and sulfonate groups increases. The pKa of 2-(cyclohexylammonio)ethanesulfonate (CHES) increases by 3.1 units upon complexation by CB[7].

Graphical abstract: Cucurbit[7]uril complexations of Good's buffers

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Publication details

The article was received on 10 Aug 2017, accepted on 27 Aug 2017 and first published on 01 Sep 2017


Article type: Paper
DOI: 10.1039/C7RA08865E
RSC Adv., 2017,7, 42513-42518
  • Open access: Creative Commons BY-NC license
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    Cucurbit[7]uril complexations of Good's buffers

    A. J. Selinger and D. H. Macartney, RSC Adv., 2017, 7, 42513
    DOI: 10.1039/C7RA08865E

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