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Issue 55, 2017
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A novel silver-loaded chitosan composite sponge with sustained silver release as a long-lasting antimicrobial dressing

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Abstract

In this study, a new kind of sustained-release silver-loaded chitosan-based sponge was developed by a simple and green method as a long-lasting antimicrobial dressing. The embedded silver nanoparticles (AgNPs) were prepared by catechol-conjugated chitosan (CCS). The CCS-coated AgNPs (CCS-AgNPs) were incorporated into the chitosan (CS) matrix through interactions between the catechol and amino groups of CS. Well-dispersed and unaggregated CCS-AgNPs were observed in the composite sponges. Due to an interconnected multi-porous structure, the composite sponges exhibited excellent flexibility and water absorption capability, which is beneficial to remove excess exudates effectively. In silver release tests, CCS-AgNPs/CS showed sustained release, whereas the control group without catechol exhibited burst release. As a bridge to bind AgNPs into the CS matrix, catechol extended the silver release time from 1 day to at least 4 days. The prolonged silver release endows CCS-AgNPs/CS sponges with long-lasting bacteriostatic effects against both Gram positive and negative bacteria. Bacterial growth was completely inhibited for up to 3 days. Meanwhile, the embedded CCS-AgNPs significantly improved the bactericidal effect. More than 99.99% bacteria could be killed by the composite sponges, which completely satisfies antibacterial requirements for wound healing. As a double-edged sword, an excessively high silver content induced cytotoxicity in MC3T3 cells. In general, the CCS-AgNPs/CS sponge with appropriate silver content (0.63 wt%) is considered as a potential candidate for wound healing dressings due to its long-lasting bacteriostatic effect, powerful bactericidal activity, and excellent biocompatibility.

Graphical abstract: A novel silver-loaded chitosan composite sponge with sustained silver release as a long-lasting antimicrobial dressing

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Article information


Submitted
08 Jun 2017
Accepted
03 Jul 2017
First published
11 Jul 2017

This article is Open Access

RSC Adv., 2017,7, 34655-34663
Article type
Paper

A novel silver-loaded chitosan composite sponge with sustained silver release as a long-lasting antimicrobial dressing

X. Huang, X. Bao, Z. Wang and Q. Hu, RSC Adv., 2017, 7, 34655
DOI: 10.1039/C7RA06430F

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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    [Original citation] - Published by The Royal Society of Chemistry.

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