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Issue 60, 2017, Issue in Progress
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Lipase-mediated synthesis of sugar–PEG-based amphiphiles for encapsulation and stabilization of indocyanine green

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Abstract

Indocyanine green (ICG) is a near-infrared dye for wide-ranging applications, but its utility for biological studies is limited due to poor aqueous stability and concentration-dependent aggregation. Aqueous polymeric micelles/micellar aggregates of amphiphilic copolymers could be used to protect indocyanine green (ICG) by encapsulation, which is used in laser-mediated photothermal therapy (PTT) and photodynamic therapy (PDT). The sugar–PEG-based amphiphilic copolymers were synthesized using Novozym 435-catalyzed transesterification reaction under bulk conditions for encapsulation of ICG. A dye loading study revealed that micelles derived from copolymers having decanoylated and myristoylated sugar moieties encapsulate 62% and 92% of the ICG, respectively, with a multi-fold increase in its aqueous stability. Furthermore, an efficient internalization of micelles of acylated amphiphilic copolymers in aqueous medium was demonstrated by incubating cells with Nile red-encapsulated amphiphiles.

Graphical abstract: Lipase-mediated synthesis of sugar–PEG-based amphiphiles for encapsulation and stabilization of indocyanine green

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Supplementary files

Article information


Submitted
03 May 2017
Accepted
20 Jul 2017
First published
31 Jul 2017

This article is Open Access

RSC Adv., 2017,7, 37534-37541
Article type
Paper

Lipase-mediated synthesis of sugar–PEG-based amphiphiles for encapsulation and stabilization of indocyanine green

V. Khatri, S. Bhatia, K. Achazi, S. Deep, E. Kohli, S. K. Sharma, R. Haag and A. K. Prasad, RSC Adv., 2017, 7, 37534
DOI: 10.1039/C7RA04994C

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