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Issue 45, 2017
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Preparation of protein imprinted polymers via protein-catalyzed eATRP on 3D gold nanodendrites and their application in biosensors

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Abstract

Sensitive detection of metalloproteins is very essential in human pathologies. Hemoglobin (Hb) was represented as a metal-containing protein to prepare protein imprinted polymers (PIPs) and used for electrochemical biosensors. The PIPs were synthesized via electrochemically mediated atom transfer radical polymerization (eATRP) with protein as, both, catalyst and template on the surface of 3D Au nanodendrites. The nanodendrites modified with PIPs could determine Hb by differential pulse voltammetry (DPV) method. A linear response from 1.0 × 10−13 to 1.0 × 10−1 mg mL−1 with a detection limit of 3.2 × 10−14 mg mL−1 (S/N = 3) for Hb was achieved from the results of the experiments. Compared with other Hb sensors based on PIPs, the broader linear range and lower detection limit suggested the promising prospect of the biosensor. In a word, this study significantly reports the preparation of PIPs, catalysis of eATRP by proteins and the sensitive detection of metalloproteins.

Graphical abstract: Preparation of protein imprinted polymers via protein-catalyzed eATRP on 3D gold nanodendrites and their application in biosensors

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Supplementary files

Article information


Submitted
01 Apr 2017
Accepted
13 May 2017
First published
30 May 2017

This article is Open Access

RSC Adv., 2017,7, 28461-28468
Article type
Paper

Preparation of protein imprinted polymers via protein-catalyzed eATRP on 3D gold nanodendrites and their application in biosensors

Y. Sun, J. Zhang, J. Li, M. Zhao and Y. Liu, RSC Adv., 2017, 7, 28461
DOI: 10.1039/C7RA03772D

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    [Original citation] - Published by The Royal Society of Chemistry.

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