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Issue 55, 2017

Biomimetic intrafibrillar silicification of collagen fibrils through a one-step collagen self-assembly/silicification approach

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Abstract

Inspired by the silicification process in nature, intrafibrillar silicified collagen fibrils were successfully fabricated using a biomimetic one-step collagen self-assembly/silicification approach, in which collagen self-assembly and intrafibrillar silicification occurred simultaneously. To the best of our knowledge, it is the first time that intrafibrillar silicified collagen fibrils were formed via a one-step simultaneous approach, where collagen fibrils served as a templating matrix, and poly(allylamine) hydrochloride and sodium tripolyphosphate acted as the respective positive and negative analogs of zwitterionic proteins. By tailoring zwitterionic proteins analogs, silicified collagen fibrils with different microstructures, including core–shell, twisted and banded structures, were achieved. The intrafibrillar silicified collagen fibrils demonstrated significant improvement in osteoblast proliferation compared with apatite mineralized collagen fibrils. These findings open a new avenue for preparation of silicon-containing hierarchical biocomposites for biomedical needs.

Graphical abstract: Biomimetic intrafibrillar silicification of collagen fibrils through a one-step collagen self-assembly/silicification approach

Supplementary files

Article information


Submitted
10 Mar 2017
Accepted
23 Jun 2017
First published
11 Jul 2017

This article is Open Access

RSC Adv., 2017,7, 34624-34632
Article type
Paper

Biomimetic intrafibrillar silicification of collagen fibrils through a one-step collagen self-assembly/silicification approach

C. Hu, L. Yu and M. Wei, RSC Adv., 2017, 7, 34624 DOI: 10.1039/C7RA02935G

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