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Issue 22, 2017
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N-Propargylic β-enaminocarbonyls: powerful and versatile building blocks in organic synthesis

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Abstract

Nitrogen-containing heterocyclic compounds are not only prevalent in an extensive number of natural products and synthetic pharmaceuticals but are also used as building blocks in organic synthesis. The efficient preparation of highly functionalized N-heterocycles from cheap and easily available starting materials has therefore become of central interest for synthetic organic chemists. This review gives an overview of new developments in synthesis of highly substituted N-heterocycles, including pyrroles, pyridines, pyrrolines, piperidines, azepines, and related compounds, from N-propargylic β-enaminocarbonyls (N-propargylic β-enaminones and β-enaminoesters) in recent years. Mechanistic aspects of the reactions are considered and discussed in detail.

Graphical abstract: N-Propargylic β-enaminocarbonyls: powerful and versatile building blocks in organic synthesis

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Publication details

The article was received on 17 Jan 2017, accepted on 14 Feb 2017 and first published on 27 Feb 2017


Article type: Review Article
DOI: 10.1039/C7RA00746A
RSC Adv., 2017,7, 13198-13211
  • Open access: Creative Commons BY license
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    N-Propargylic β-enaminocarbonyls: powerful and versatile building blocks in organic synthesis

    S. Arshadi, E. Vessally, L. Edjlali, E. Ghorbani-Kalhor and R. Hosseinzadeh-Khanmiri, RSC Adv., 2017, 7, 13198
    DOI: 10.1039/C7RA00746A

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