Issue 25, 2017

A poly(amidoamine) dendrimer-based drug carrier for delivering DOX to gliomas cells

Abstract

A drug delivery carrier G4–FA–PEG with PEG and FA modified on the periphery of G4.0 poly(amidoamine) (PAMAM) dendrimer was synthesized, and doxorubicin (DOX) was encapsulated in the interior. The in vitro cytotoxicity and cellular uptake in gliomas cells were both enhanced via a FR-mediated endocytosis pathway.

Graphical abstract: A poly(amidoamine) dendrimer-based drug carrier for delivering DOX to gliomas cells

Supplementary files

Article information

Article type
Paper
Submitted
17 Jan 2017
Accepted
03 Mar 2017
First published
08 Mar 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 15475-15481

A poly(amidoamine) dendrimer-based drug carrier for delivering DOX to gliomas cells

Y. Li, H. He, W. Lu and X. Jia, RSC Adv., 2017, 7, 15475 DOI: 10.1039/C7RA00713B

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