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Issue 22, 2017
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Ultrasensitive and in situ DNA detection in various pH environments based on a microfiber with a graphene oxide linking layer

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Abstract

Ultrasensitive and in situ DNA detection at different pH values, ranging from 4.3 to 8.5, based on a microfiber with a graphene oxide linking layer was proposed and experimentally demonstrated. The graphene oxide coating over the silica microfiber provides a strong π–π interaction with the detected single-stranded DNA molecules, and induces an amplified surface refractive index modulation over the fiber, and finally leads to a wavelength shift of the optical interference fringe for interrogation. Using this strategy, in situ DNA measurement with a detection limit of up to 10−12 M and a linear response in the pH range from 4.3–8.5 has been achieved. Benefiting from its compact size, high sensitivity, and ease of use, together with remote operational ability, the proposed sensor opens up a multitude of opportunities for quantifying DNA in various hard-to-reach environments. It may supplement the existing DNA detection tools.

Graphical abstract: Ultrasensitive and in situ DNA detection in various pH environments based on a microfiber with a graphene oxide linking layer

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Publication details

The article was received on 05 Jan 2017, accepted on 15 Feb 2017 and first published on 24 Feb 2017


Article type: Paper
DOI: 10.1039/C7RA00170C
RSC Adv., 2017,7, 13177-13183
  • Open access: Creative Commons BY license
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    Ultrasensitive and in situ DNA detection in various pH environments based on a microfiber with a graphene oxide linking layer

    Y. Huang, B. Yu, T. Guo and B. Guan, RSC Adv., 2017, 7, 13177
    DOI: 10.1039/C7RA00170C

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