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Issue 23, 2017, Issue in Progress

Rapid synthesis for monodispersed gold nanoparticles in kaempferol and anti-leishmanial efficacy against wild and drug resistant strains

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Abstract

Leishmaniasis is a WHO notified neglected tropical disease (NTD) caused by the Leishmania parasite species. The parasite locates rapidly in the macrophage cells and survives there for a long period of time with or without any symptomatic response. Eliminating Leishmania from the macrophage sites is complicated. Only a few antileishmanial drugs are known and most of them have developed resistance over the time. We have synthesized highly monodispersed gold nanoparticles (KAunp) in a rapid reduction reaction catalyzed in kaempferol. Kaempferol stabilized nanoparticles in 18.24 nm size domain were used as leishmanicidals in macrophage infested conditions. KAunps' CC50 in the macrophages was at 2.4 × 102 μM while that for sodium stibogluconate was 27 μM. Phagocytic uptake in infested cells was fast and remarkable. KAunps were explicitly effective against both the wild and drug resistant organisms. Monodispersed gold nanoparticles synthesized in green technology appeared as safer alternatives for leishmanial chemotherapy.

Graphical abstract: Rapid synthesis for monodispersed gold nanoparticles in kaempferol and anti-leishmanial efficacy against wild and drug resistant strains

Article information


Submitted
23 Dec 2016
Accepted
17 Feb 2017
First published
02 Mar 2017

This article is Open Access

RSC Adv., 2017,7, 14159-14167
Article type
Paper

Rapid synthesis for monodispersed gold nanoparticles in kaempferol and anti-leishmanial efficacy against wild and drug resistant strains

A. Halder, S. Das, T. Bera and A. Mukherjee, RSC Adv., 2017, 7, 14159 DOI: 10.1039/C6RA28632A

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