Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 10, 2017
Previous Article Next Article

Two decades of new drug discovery and development for Alzheimer's disease

Author affiliations

Abstract

Alzheimer's disease is a progressive and irreversible neurodegenerative disease, associated with a decreased cognitive function and severe behavioral abnormalities. Due to its complex pathophysiological characteristics, complicated interactions with a large number of genes and proteins, there is still no effective drug treatment of the disease. Amyloid cascade aggregation of senile plaques and hyperphosphorylation of Tau protein to form neurofibrillary tangles are the main pathological features of Alzheimer's disease, other mechanisms, such as oxidative stress, lack of central cholinergic neurotransmitters, inflammatory reaction and toxic metal ions have also been involved. The purpose of this review is to briefly introduce the progress of the development of the therapeutic agents based on their main mechanisms of action.

Graphical abstract: Two decades of new drug discovery and development for Alzheimer's disease

Back to tab navigation

Supplementary files

Article information


Submitted
13 Nov 2016
Accepted
16 Dec 2016
First published
18 Jan 2017

This article is Open Access

RSC Adv., 2017,7, 6046-6058
Article type
Review Article

Two decades of new drug discovery and development for Alzheimer's disease

Z. Liu, A. Zhang, H. Sun, Y. Han, L. Kong and X. Wang, RSC Adv., 2017, 7, 6046
DOI: 10.1039/C6RA26737H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements