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Issue 2, 2017
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Electrochemical design of a new nanosensor based on cobalt nanoparticles, chitosan and MWCNT for the determination of daclatasvir: a hepatitis C antiviral drug

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Abstract

Daclatasvir (DAC) is listed on the World Health Organization's list of essential medicines needed in a basic health system, therefore, electrochemical and impedance spectroscopic methods are necessary to obtain information about its mechanism using a carbon paste electrode (CPE) modified with chitosan (Cs)/multi-walled carbon nanotubes (CNT) and cobalt nanoparticles (CoNps). The simultaneous determination of DAC with the hepatitis B antiviral drug entecavir (ENT) was also investigated by differential pulse voltammetry in universal buffer pH 2.0. The experimental results specify a linear relation between the DAC peak current and its concentration in the range from 1.0 nM to 12 μM, leading to a detection limit of 8.82 × 10−10 M. Finally, this novel sensor was successfully used to determine DAC in human biological fluids such as urine, blood serum and in pharmaceutical formulations.

Graphical abstract: Electrochemical design of a new nanosensor based on cobalt nanoparticles, chitosan and MWCNT for the determination of daclatasvir: a hepatitis C antiviral drug

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Publication details

The article was received on 25 Oct 2016, accepted on 28 Nov 2016 and first published on 04 Jan 2017


Article type: Paper
DOI: 10.1039/C6RA25826C
RSC Adv., 2017,7, 1118-1126
  • Open access: Creative Commons BY license
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    Electrochemical design of a new nanosensor based on cobalt nanoparticles, chitosan and MWCNT for the determination of daclatasvir: a hepatitis C antiviral drug

    Shereen M. Azab and A. M. Fekry, RSC Adv., 2017, 7, 1118
    DOI: 10.1039/C6RA25826C

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