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Nine new compounds from the root bark of Lycium chinense and their α-glucosidase inhibitory activity

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Abstract

Lycium chinense Mill. is a deciduous shrub in the Solanaceae family that is known for its fruits (Lycii fructus) and root bark (Lycii cortex). In our ongoing search for α-glucosidase inhibitors from the root bark of L. chinense, lyciumflavane A, one new flavane with an unusual benzofuran unit, one new amide possessing a naphthalene skeleton, one new sesquiterpene, three new lignan glucosides, and three new phenolic glucosides were isolated along with eight known compounds. Their structures were elucidated using NMR, HRESIMS, UV, ECD, and IR spectroscopic data. Their α-glucosidase inhibitory activity was screened using acarbose as a positive control (IC50 = 385 μM). Compound 1 showed strong inhibitory activity against α-glucosidase (IC50 = 20.89 μM).

Graphical abstract: Nine new compounds from the root bark of Lycium chinense and their α-glucosidase inhibitory activity

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Publication details

The article was received on 05 Oct 2016, accepted on 21 Oct 2016 and first published on 03 Jan 2017


Article type: Paper
DOI: 10.1039/C6RA24751B
RSC Adv., 2017,7, 805-812
  • Open access: Creative Commons BY license
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    Nine new compounds from the root bark of Lycium chinense and their α-glucosidase inhibitory activity

    Y. Yang, Y. An, Z. Zhan, J. Xie, J. Jiang, Z. Feng, F. Ye and P. Zhang, RSC Adv., 2017, 7, 805
    DOI: 10.1039/C6RA24751B

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