Issue 82, 2016, Issue in Progress
From the journal:

RSC Advances

Synthesis of 1-azulenyl ketones by Brønsted acid mediated hydration of 1-azulenylalkynes†

Taku Shoji,*a   Miwa Tanaka,a   Takanori Araki,a   Sho Takagaki,a   Ryuta Sekiguchib  and  Shunji Itob  

* Corresponding authors

a Graduate School of Science and Technology, Shinshu University, Matsumoto 390-8621, Japan
E-mail: tshoji@shinshu-u.ac.jp

b Graduate School of Science and Technology, Hirosaki University, Hirosaki 036-8561, Japan

Abstract

Preparation of 1-azulenyl ketones was achieved by metal-free hydration of 1-azulenylalkynes using trifluoroacetic acid as a Brønsted acid in good to excellent yields. The reaction was accomplished at a relatively low temperature with complete regioselectivity and compatibility of several functional groups.

Graphical abstract: Synthesis of 1-azulenyl ketones by Brønsted acid mediated hydration of 1-azulenylalkynes

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Article information

DOI
https://doi.org/10.1039/C6RA20010A
Article type
Communication
Submitted
08 Aug 2016
Accepted
12 Aug 2016
First published
12 Aug 2016

RSC Adv., 2016,6, 78303-78306

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Synthesis of 1-azulenyl ketones by Brønsted acid mediated hydration of 1-azulenylalkynes

T. Shoji, M. Tanaka, T. Araki, S. Takagaki, R. Sekiguchi and S. Ito, RSC Adv., 2016, 6, 78303 DOI: 10.1039/C6RA20010A

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