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Issue 84, 2016, Issue in Progress
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Elemental sulfur mediated synthesis of benzoxazoles, benzothiazoles and quinoxalines via decarboxylative coupling of 2-hydroxy/mercapto/amino-anilines with cinnamic acids

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Abstract

An easy and practical method has been developed for the synthesis of 2-benzylbenzoxazoles and 2-benzylbenzothiazoles using sulfur mediated decarboxylative coupling of cinnamic acids with 2-hydroxyanilines and 2-mercaptoanilines respectively under metal- and solvent-free conditions. However, the reaction of 2-aminoanilines with cinnamic acids leads to the formation of 2-arylquinoxalines under the same set of reaction conditions. The transformation is versatile and compatible with a number of functional groups.

Graphical abstract: Elemental sulfur mediated synthesis of benzoxazoles, benzothiazoles and quinoxalines via decarboxylative coupling of 2-hydroxy/mercapto/amino-anilines with cinnamic acids

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Publication details

The article was received on 08 Jul 2016, accepted on 18 Aug 2016 and first published on 19 Aug 2016


Article type: Paper
DOI: 10.1039/C6RA17491D
Citation: RSC Adv., 2016,6, 81013-81016

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    Elemental sulfur mediated synthesis of benzoxazoles, benzothiazoles and quinoxalines via decarboxylative coupling of 2-hydroxy/mercapto/amino-anilines with cinnamic acids

    T. Guntreddi, R. Vanjari, S. Kumar, R. Singh, N. Singh, P. Kumar and K. N. Singh, RSC Adv., 2016, 6, 81013
    DOI: 10.1039/C6RA17491D

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