Jump to main content
Jump to site search

Issue 86, 2016
Previous Article Next Article

Nontoxic and renewable metal–organic framework based on α-cyclodextrin with efficient drug delivery

Author affiliations

Abstract

A novel α-cyclodextrin based metal–organic framework (CD-MOF) with chiral helices, K3(C36H60O30)2·7H2O (1), was synthesized by vapor diffusion method, which contains infinitely long left-handed helical chains, interdigitated with six circumambient helical chains. Compound 1 exhibits efficient drug loading capacity and excellent sustained release behavior. In addition, by changing the synthetic method, another compound based on α-cyclodextrin, (C36H60O30)·H2O (2), was isolated by solvothermal synthesis, which contains left-handed chiral helical double channels, linked with adjacent four same helical channels. Moreover, the lower cytotoxicity of the two compounds indicates that they are a type of renewable, environmentally friendly and biocompatible drug carrier material.

Graphical abstract: Nontoxic and renewable metal–organic framework based on α-cyclodextrin with efficient drug delivery

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Jun 2016, accepted on 16 Aug 2016 and first published on 19 Aug 2016


Article type: Paper
DOI: 10.1039/C6RA16549D
RSC Adv., 2016,6, 82977-82983

  •   Request permissions

    Nontoxic and renewable metal–organic framework based on α-cyclodextrin with efficient drug delivery

    J. Sha, X. Zhong, L. Wu, G. Liu and N. Sheng, RSC Adv., 2016, 6, 82977
    DOI: 10.1039/C6RA16549D

Search articles by author

Spotlight

Advertisements