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Issue 95, 2016, Issue in Progress
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Room-temperature fabrication of a three-dimensional reduced-graphene oxide/polypyrrole/hydroxyapatite composite scaffold for bone tissue engineering

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Abstract

The development of tissue engineering (TE) provides a promising alternative strategy for bone healing and regeneration. For the successful application of TE, a scaffold with a three-dimensional (3D) hierarchical structure is required to provide sites for cell adhesion and proliferation. In the present study, by using nickel foam (NF) as a template, we reported a simple but low-cost strategy to fabricate 3D reduced-graphene oxide (rGO) and 3D rGO/polypyrrole (3D rGO/PPY) struts through an electrostatic layer-by-layer assembly strategy followed by an electrochemical deposition process. The results indicated that both 3D rGO and rGO/PPY could replicate the morphology of NF, while the 3D rGO/PPY exhibits better mechanical property and can be processed into the desired configuration. After mineralization, the 3D rGO/PPY/HA scaffold can keep MC3T3-E1 cells at an active proliferation state with 6.6 times upregulation at the 4th day, superior to that of the 3D rGO/PPY scaffold (5.27 times) and control group. The excellent osteoblastic performance of the 3D rGO/PPY/HA scaffold can be attributed to the good biocompatibility of HA, and the unique 3D macro-/nano-hierarchical binary structure with high specific surface area and large surface roughness. Our finding suggests that the mineralized 3D rGO/PPY can be considered as an attractive scaffold for bone healing and regeneration in the future.

Graphical abstract: Room-temperature fabrication of a three-dimensional reduced-graphene oxide/polypyrrole/hydroxyapatite composite scaffold for bone tissue engineering

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Supplementary files

Article information


Submitted
15 Jun 2016
Accepted
08 Sep 2016
First published
20 Sep 2016

RSC Adv., 2016,6, 92804-92812
Article type
Paper

Room-temperature fabrication of a three-dimensional reduced-graphene oxide/polypyrrole/hydroxyapatite composite scaffold for bone tissue engineering

F. Song, W. Jie, T. Zhang, W. Li, Y. Jiang, L. Wan, W. Liu, X. Li and B. Liu, RSC Adv., 2016, 6, 92804
DOI: 10.1039/C6RA15267H

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