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Issue 70, 2016, Issue in Progress
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Ethanol promoted titanocene Lewis acid catalyzed synthesis of quinazoline derivatives

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Abstract

An efficient catalytic system involving in situ activation of kinetically inert titanocene dichloride with alcoholic solvent for the synthesis of quinazoline derivatives was developed. 1 mol% Cp2TiCl2 at 30 °C afforded 17 examples of quinazoline derivatives with yields of 95–98% in 7–12 minutes. Mechanistic experiments using in situ NMR and HRMS established that the coordination of ethanol to the titanocene moiety released the catalytic species [Cp2Ti(OCH2CH3)2].

Graphical abstract: Ethanol promoted titanocene Lewis acid catalyzed synthesis of quinazoline derivatives

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Article information


Submitted
05 Jun 2016
Accepted
27 Jun 2016
First published
29 Jun 2016

RSC Adv., 2016,6, 66074-66077
Article type
Communication
Author version available

Ethanol promoted titanocene Lewis acid catalyzed synthesis of quinazoline derivatives

Y. Luo, Y. Wu, Y. Wang, H. Sun, Z. Xie, W. Zhang and Z. Gao, RSC Adv., 2016, 6, 66074
DOI: 10.1039/C6RA14583C

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