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Issue 94, 2016, Issue in Progress
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Oleiferasaponin C6 from the seeds of Camellia oleifera Abel.: a novel compound inhibits proliferation through inducing cell-cycle arrest and apoptosis on human cancer cell lines in vitro

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Abstract

A new oleanane-type saponin oleiferasaponin C6 (OSC6) was isolated and identified from Camellia oleifera seeds through NMR, HR-ESI-MS, and GC-MS spectroscopic methods. This new oleanane-type saponin exhibits potent cytotoxic activities on five human cancer cell lines (BEL-7402, BGC-823, MCF-7, HL-60 and KB), especially in HL-60 and BEL-7402 cell lines. The action mechanism of the anti-cancer activity of OSC6 was further investigated and it showed significant induction of cell cycle arrest and apoptosis in HL-60 and BEL-7402 cell lines by down-regulating CDK4, cyclin D1 and Bcl-2; up-regulating p21, caspase-3/9, p-p53 and Bax protein expression in vitro. These results suggested that the newly isolated saponin OSC6 is a potential therapeutic agent for the treatment of human cancer.

Graphical abstract: Oleiferasaponin C6 from the seeds of Camellia oleifera Abel.: a novel compound inhibits proliferation through inducing cell-cycle arrest and apoptosis on human cancer cell lines in vitro

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Supplementary files

Article information


Submitted
03 Jun 2016
Accepted
17 Sep 2016
First published
19 Sep 2016

RSC Adv., 2016,6, 91386-91393
Article type
Paper

Oleiferasaponin C6 from the seeds of Camellia oleifera Abel.: a novel compound inhibits proliferation through inducing cell-cycle arrest and apoptosis on human cancer cell lines in vitro

J. Zong, D. Wang, W. Jiao, L. Zhang, G. Bao, C. Ho, R. Hou and X. Wan, RSC Adv., 2016, 6, 91386
DOI: 10.1039/C6RA14467E

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