Metal ion binding of the third and fourth domains of Slc11a1 in a model membrane

Abstract

Differential scanning calorimetric (DSC) experiments have shown that the ability of third and fourth transmembrane domains of Slc11a1 to perturb DMPC model membranes is affected by metal ions. The results indicate the third and fourth transmembrane Domains of Slc11a1 can bind with metal ions. Our findings may be helpful in understanding the transport mechanism of Slc11a1.