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Issue 76, 2016
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Decarboxylative/Sonogashira-type cross-coupling using PdCl2(Cy*Phine)2

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Abstract

The PdCl2(Cy*Phine)2 precatalyst containing the meta-terarylphosphine ligand, Cy*Phine, can effectively mediate decarboxylative cross-coupling with a diverse range of (hetero-)aryl, aryl and alkyl chlorides including those with unprotected functionality. Using a facile and robust protocol, this process was extended to the first synthesis of symmetrical di(heteroaryl)alkynes via tandem Sonogashira/decarboxylative cross-coupling of heteroaryl chlorides and propiolic acid.

Graphical abstract: Decarboxylative/Sonogashira-type cross-coupling using PdCl2(Cy*Phine)2

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Supplementary files

Article information


Submitted
18 May 2016
Accepted
26 Jul 2016
First published
27 Jul 2016

RSC Adv., 2016,6, 72810-72814
Article type
Paper

Decarboxylative/Sonogashira-type cross-coupling using PdCl2(Cy*Phine)2

Y. Yang, Y. H. Lim, E. G. Robins and C. W. Johannes, RSC Adv., 2016, 6, 72810
DOI: 10.1039/C6RA12916A

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