Decarboxylative/Sonogashira-type cross-coupling using PdCl2(Cy*Phine)2

Abstract

The PdCl₂(Cy*Phine)₂ precatalyst containing the meta-terarylphosphine ligand, Cy*Phine, can effectively mediate decarboxylative cross-coupling with a diverse range of (hetero-)aryl, aryl and alkyl chlorides including those with unprotected functionality. Using a facile and robust protocol, this process was extended to the first synthesis of symmetrical di(heteroaryl)alkynes via tandem Sonogashira/decarboxylative cross-coupling of heteroaryl chlorides and propiolic acid.