MOF-253-Pd(OAc)2: a recyclable MOF for transition-metal catalysis in water

Abstract

We report palladium(II)-functionalized MOF-253 (MOF-253-Pd(OAc)₂) as a recyclable catalyst to form all-carbon quaternary centers via conjugate additions of arylboronic acids to β,β-disubstituted enones in aqueous media. We demonstrate MOF-253-Pd(OAc)₂ can be reused 8 times to form ketone products in yields above 75% while maintaining its crystallinity. Additions of a range of stereoelectronically diverse arylboronic acids to a variety of β,β-disubstituted enones catalyzed by MOF-253-Pd(OAc)₂ occur in modest-to-high yields (34–95%).