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Issue 75, 2016
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Fabrication of a novel chitosan scaffold with asymmetric structure for guided tissue regeneration

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Abstract

A novel chitosan (CS)-based asymmetric scaffold composed of a dense layer and a loose layer was fabricated via the self-deposition approach. The micro-structure and mechanical properties were verified to satisfy the criteria for the guided tissue regeneration (GTR) membrane. The in vitro biocompatibility of the scaffold was verified by the CCK-8 assays of MC3T3 osteoblastic cells. The rat skull defect model was applied to estimate the in vivo bone regeneration performance. The micro-CT and histological results manifested its outstanding bone regenerative ability and superior degradability over the Bio-gideĀ® membrane. Considering the relative low expense and simple fabrication process, the prepared asymmetric CS scaffold is a prospective candidate for GTR therapy.

Graphical abstract: Fabrication of a novel chitosan scaffold with asymmetric structure for guided tissue regeneration

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Publication details

The article was received on 12 May 2016, accepted on 05 Jul 2016 and first published on 11 Jul 2016


Article type: Paper
DOI: 10.1039/C6RA12370H
Citation: RSC Adv., 2016,6, 71567-71573

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    Fabrication of a novel chitosan scaffold with asymmetric structure for guided tissue regeneration

    L. Yang, W. Lu, Y. Pang, X. Huang, Z. Wang, A. Qin and Q. Hu, RSC Adv., 2016, 6, 71567
    DOI: 10.1039/C6RA12370H

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