Issue 62, 2016
From the journal:

RSC Advances

A facile and efficient method for the synthesis of 1,2,4-trisubstituted imidazoles with enamides and benzylamines†

Jinhui Cao,a   Xiaoqiang Zhou, ORCID logo a   Haojie Ma,a   Chong Shia  and  Guosheng Huang*a  

* Corresponding authors

a State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Department of Chemistry, Lanzhou University, Lanzhou, China
E-mail: hgs@lzu.edu.cn
Fax: +86-931-8912582

Abstract

A novel and practical method for the construction of 1,2,4-trisubstituted imidazoles with enamides and benzylamines catalysed by CuBr and I2 has been developed. This sustainable, simple and environmentally-friendly procedure tolerates various functional groups and affords a series of trisubstitued imidazoles.

Graphical abstract: A facile and efficient method for the synthesis of 1,2,4-trisubstituted imidazoles with enamides and benzylamines

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Article information

DOI
https://doi.org/10.1039/C6RA08174F
Article type
Communication
Submitted
30 Mar 2016
Accepted
08 Jun 2016
First published
08 Jun 2016

RSC Adv., 2016,6, 57232-57235

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A facile and efficient method for the synthesis of 1,2,4-trisubstituted imidazoles with enamides and benzylamines

J. Cao, X. Zhou, H. Ma, C. Shi and G. Huang, RSC Adv., 2016, 6, 57232 DOI: 10.1039/C6RA08174F

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