Jump to main content
Jump to site search

Issue 88, 2016
Previous Article Next Article

Au nanoshell-coated superparamagnetic Fe3O4–silica composite nanoparticles with surface-modification of an activatable cell-penetrating peptide for tumor-targeted multimode bioimaging and photothermal therapy

Author affiliations

Abstract

High-resolution imaging of molecules intrinsically involved in malignancy and metastasis would be of great value for clinical detection and staging of tumors. Based on the selective cell-penetrating ability in the tumor sites of the activatable cell-penetrating peptide (ACPP), the superparamagnetic Fe3O4–silica composite nanoparticles (SSCNs) coated with Au nanoshells (AuNSs) were prepared and subsequently surface-modified with polyethylene glycol (PEG) conjugated an ACPP to form SSCNs@AuNSs-PEG-ACPP nanoparticles for realizing tumor site-specific multimode bioimaging and photothermal therapy. SSCNs@AuNSs-PEG-ACPP nanoparticles showed high photothermal efficiency, X-ray attenuation property and T2 relaxation rate, which were confirmed by a series of characterizations in vitro and in vivo. The enhanced accumulation of SSCNs@AuNSs-PEG-ACPP nanoparticles in the tumor was investigated by the in vivo X-ray computed tomography (CT) imaging and magnetic resonance (MR) imaging. SSCNs@AuNSs-PEG-ACPP nanoparticles will be likely to realize simultaneous CT/MR bioimaging and photothermal therapy on the tumor by the combination of superparamagnetization, X-ray attenuation property, near-infrared (NIR) absorption and tumor-selected accumulation.

Graphical abstract: Au nanoshell-coated superparamagnetic Fe3O4–silica composite nanoparticles with surface-modification of an activatable cell-penetrating peptide for tumor-targeted multimode bioimaging and photothermal therapy

Back to tab navigation

Publication details

The article was received on 24 Mar 2016, accepted on 22 Aug 2016 and first published on 25 Aug 2016


Article type: Paper
DOI: 10.1039/C6RA07708K
RSC Adv., 2016,6, 85587-85594

  •   Request permissions

    Au nanoshell-coated superparamagnetic Fe3O4–silica composite nanoparticles with surface-modification of an activatable cell-penetrating peptide for tumor-targeted multimode bioimaging and photothermal therapy

    Y. Jiang, Q. Zhang, X. Liu, Y. Chen, L. Wang, J. Fu, H. Duan, Y. Wang and X. Yang, RSC Adv., 2016, 6, 85587
    DOI: 10.1039/C6RA07708K

Search articles by author

Spotlight

Advertisements