Issue 46, 2016
From the journal:

RSC Advances

Synthesis of highly functionalized 2-thiaspiro[4.5]deca-6,8-dienes via atom efficient tandem Michael addition/Thorpe–Ziegler cyclization†

Mani Anusha Rani,a   Sundaravel Vivek Kumar,a   Somi Santharam Roja,a   Abdulrahman I. Almansour,b   Raju Suresh Kumar,b   S. Athimoolamc  and  Raju Ranjith Kumar*a  

* Corresponding authors

a Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai-625 021, Tamil Nadu, India
E-mail: raju.ranjithkumar@gmail.com
Fax: +91-9655591445
Tel: +91-9655591445

b Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia

c Department of Physics, University College of Engineering, Anna University Constituent College, Nagercoil 629 004, Tamil Nadu, India

Abstract

The two-component reaction of 2,4-bis((Z)-arylidene)dihydrothiophen-3(2H)-ones and 2-(1-arylethylidene)malononitriles proceeded through a tandem chemoselective Michael addition–tautomerization–Thorpe–Ziegler cyclization sequence of reactions in a single step affording novel 2-thiaspiro[4.5]deca-6,8-dienes in quantitative yields.

Graphical abstract: Synthesis of highly functionalized 2-thiaspiro[4.5]deca-6,8-dienes via atom efficient tandem Michael addition/Thorpe–Ziegler cyclization

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Article information

DOI
https://doi.org/10.1039/C6RA05572A
Article type
Paper
Submitted
02 Mar 2016
Accepted
14 Apr 2016
First published
15 Apr 2016

RSC Adv., 2016,6, 40585-40592

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Synthesis of highly functionalized 2-thiaspiro[4.5]deca-6,8-dienes via atom efficient tandem Michael addition/Thorpe–Ziegler cyclization

M. A. Rani, S. V. Kumar, S. S. Roja, A. I. Almansour, R. S. Kumar, S. Athimoolam and R. R. Kumar, RSC Adv., 2016, 6, 40585 DOI: 10.1039/C6RA05572A

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