CuI assisted desulfurative Sonogashira reaction of mercapto N-heterocyclic derivatives with alkynes

Abstract

A palladium catalyzed Sonogashira reaction of mercapto N-heterocyclic derivatives with terminal alkynes by using CuI as the desulfurative reagent was described in this report. It provided an effective strategy for obtaining sp–sp² cross-coupling products in good yields. The reaction mechanism was also investigated by density functional theory (DFT) calculation.