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Issue 39, 2016, Issue in Progress
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p-tert-Butylthiacalix[4]arenes equipped with guanidinium fragments: aggregation, cytotoxicity, and DNA binding abilities

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Abstract

Mono-, di- and tetracationic thiacalix[4]arenes in a 1,3-alternate conformation functionalized with guanidinium groups showed a strong dependence of the aggregation properties with the ratio of guanidinium/n-decyl fragments attached to phenolic groups. Increasing the amount of guanidinium fragments improved the macrocycles solubility in water as well as the sorption capacity towards polynucleotide molecules. The synthesized thiacalixarenes showed relatively high toxicity comparable with that for similar receptors based on the classical calixarene.

Graphical abstract: p-tert-Butylthiacalix[4]arenes equipped with guanidinium fragments: aggregation, cytotoxicity, and DNA binding abilities

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Supplementary files

Article information


Submitted
22 Feb 2016
Accepted
16 Mar 2016
First published
21 Mar 2016

RSC Adv., 2016,6, 32722-32726
Article type
Paper
Author version available

p-tert-Butylthiacalix[4]arenes equipped with guanidinium fragments: aggregation, cytotoxicity, and DNA binding abilities

A. Galukhin, I. Imatdinov and Y. Osin, RSC Adv., 2016, 6, 32722
DOI: 10.1039/C6RA04733E

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