Issue 50, 2016, Issue in Progress

Janus Au–mesoporous silica nanocarriers for chemo-photothermal treatment of liver cancer cells

Abstract

The combination of chemotherapy and photothermotherapy is emerging as a promising strategy for the treatment of liver cancer as a result of its synergistic efficacy. A safe and efficient drug-delivery system is highly desirable to ensure that the anticancer drug and photothermal agent can be simultaneously delivered to a tumor region to exert their synergistic effect with reduced side-effects. Uniform Janus Au–mesoporous silica nanoparticles with superior surface plasmon resonance properties and a high surface area were designed to integrate a high drug-loading capacity, pH-responsive properties, and a superior photothermal effect into a single carrier. The ability of the Janus nanoparticles loaded with doxorubicin to combine local specific chemotherapy with external near-infrared photothermotherapy significantly improved the therapeutic efficacy against liver cancer cells while exerting less toxicity on normal liver cells. Hence the reported doxorubicin-loaded Janus NPs may be promising therapeutic agents for efficacious and safe treatment of liver cancer.

Graphical abstract: Janus Au–mesoporous silica nanocarriers for chemo-photothermal treatment of liver cancer cells

Article information

Article type
Paper
Submitted
16 Feb 2016
Accepted
22 Apr 2016
First published
25 Apr 2016

RSC Adv., 2016,6, 44498-44505

Janus Au–mesoporous silica nanocarriers for chemo-photothermal treatment of liver cancer cells

Z. Wang, Y. Wang, M. Lu, L. Li, Y. Zhang, X. Zheng, D. Shao, J. Li and W. Dong, RSC Adv., 2016, 6, 44498 DOI: 10.1039/C6RA04183C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements