EBC-318 and 339: bicyclo[10.2.1]alkanes from Croton insularis†
Abstract
Two new crotinsulidanes EBC-318 and EBC-339 were isolated from the Australian rain forest plant Croton insularis. Both compounds are characterised by a bicyclo[10.2.1]alkane skeleton, one of which contains a bridgehead double bond. Cancer cell line cytotoxicity and biosynthetic considerations are presented.