Phosphine-catalyzed domino reactions of alkynyl ketones with sulfonylhydrazones: construction of diverse pyrazoloquinazoline derivatives

Abstract

An efficient method for the synthesis of C-1 position acyl substituted pyrazoloquinazoline derivatives via a PBu₃-promoted regioselective domino process of sulfonylhydrazones and alkynyl ketones was developed, which may be potentially useful for drug discovery.