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Issue 27, 2016
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Isolation, resolution and biological evaluation of pestalachlorides E and F containing both point and axial chirality

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Abstract

Marine life forms are an important source of structurally diverse and biologically active natural products. As a unique case of both enantiomeric and atropisomeric isomers being present in one marine natural product structure, two new dichlorinated diphenylmethanes containing both point and axial chirality, (±)-pestalachlorides E (1) and F (2), were isolated from a marine-derived Pestalotiopsis (ZJ-2009-7-6) fungus. Both of them showed potent antifouling activities against the larval settlement of the barnacle Balanus amphitrite at nontoxic concentrations with EC50 values of 1.65 and 0.55 μg mL−1, respectively, and antifouling activity was detected for the first time for this class of metabolites.

Graphical abstract: Isolation, resolution and biological evaluation of pestalachlorides E and F containing both point and axial chirality

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Publication details

The article was received on 06 Jan 2016, accepted on 21 Feb 2016 and first published on 22 Feb 2016


Article type: Paper
DOI: 10.1039/C6RA00374E
RSC Adv., 2016,6, 22653-22658

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    Isolation, resolution and biological evaluation of pestalachlorides E and F containing both point and axial chirality

    Q. Xing, L. Gan, X. Mou, W. Wang, C. Wang, M. Wei and C. Shao, RSC Adv., 2016, 6, 22653
    DOI: 10.1039/C6RA00374E

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