Issue 12, 2016
From the journal:

RSC Advances

A tumor-targeting protein nanoparticle based on Tat peptide and enhanced green fluorescent protein†

Xingang Guan,*ab   Chun Li,c   Dan Wang,c   Weiqi Sund  and  Xiaodong Gai*c  

* Corresponding authors

a Life Science Research Center, Beihua University, Jilin 132013, P. R. China
E-mail: guanxg@ciac.ac.cn

b State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China

c School of Basic Medical Sciences, Beihua University, Jilin 132013, P. R. China
E-mail: bhdxgaixiaodong@126.com

d School of Public Health, Beihua University, Jilin 132013, P. R. China

Abstract

A protein-based nanoparticle containing cell penetrating peptides (CPPs) and enhanced green fluorescent protein (EGFP) was developed through a genetic engineering method. In addition to high stability and good biocompatibility, this fluorescent protein nanoparticle also displayed preferential tumor accumulation, indicating its potential application in tumor imaging and anti-cancer drug delivery.

Graphical abstract: A tumor-targeting protein nanoparticle based on Tat peptide and enhanced green fluorescent protein

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Article information

DOI
https://doi.org/10.1039/C5RA27411G
Article type
Communication
Submitted
22 Dec 2015
Accepted
15 Jan 2016
First published
18 Jan 2016

RSC Adv., 2016,6, 9461-9464

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A tumor-targeting protein nanoparticle based on Tat peptide and enhanced green fluorescent protein

X. Guan, C. Li, D. Wang, W. Sun and X. Gai, RSC Adv., 2016, 6, 9461 DOI: 10.1039/C5RA27411G

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