Issue 3, 2016
From the journal:

RSC Advances

Improved cellular infiltration into 3D interconnected microchannel scaffolds formed by using melt-spun sacrificial microfibers†

Zongliang Wang,ac   Tianlin Gao,b   Liguo Cui,a   Yu Wang,a   Peibiao Zhang*a  and  Xuesi Chena  

* Corresponding authors

a Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
E-mail: zhangpb@ciac.ac.cn
Fax: +86 431 85262058
Tel: +86 431 85262058

b School of Public Health, Jilin University, Changchun, P. R. China

c University of Chinese Academy of Sciences, Beijing 100039, P. R. China

Abstract

We report a novel fabrication method using melt-spun sacrificial microfibers to make 3D interconnected microchannel scaffolds for improved cellular infiltration. The uniformly distributed cells in the highly porous microchannel scaffold maintained high cellular viability and glycosaminoglycan secretion indicating the good interconnectivity facilitates the smooth delivery of cells throughout the scaffold and allows sufficient oxygen and nutrient mass transport into the scaffold.

Graphical abstract: Improved cellular infiltration into 3D interconnected microchannel scaffolds formed by using melt-spun sacrificial microfibers

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Article information

DOI
https://doi.org/10.1039/C5RA25142G
Article type
Communication
Submitted
26 Nov 2015
Accepted
18 Dec 2015
First published
22 Dec 2015

RSC Adv., 2016,6, 2131-2134

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Improved cellular infiltration into 3D interconnected microchannel scaffolds formed by using melt-spun sacrificial microfibers

Z. Wang, T. Gao, L. Cui, Y. Wang, P. Zhang and X. Chen, RSC Adv., 2016, 6, 2131 DOI: 10.1039/C5RA25142G

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