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Issue 17, 2016
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Synthesis of luminescent squaramide monoesters: cytotoxicity and cell imaging studies in HeLa cells

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Abstract

Novel luminescent squaramide monoesters functionalised with different fluorophore groups have been synthesised and explored in cell imaging for the first time. Cytotoxicity studies performed in HeLa cervical cancer cells revealed high activity for some of these novel structures, highlighting the importance of the fluorescent fragment in the efficiency of these promising anticancer agents. In addition, fluorescence cell microscopy disclosed the different biodistribution behaviour depending on the fluorescent moiety, and the possibility of nuclear localisation of chiral non planar squaramide monoesters.

Graphical abstract: Synthesis of luminescent squaramide monoesters: cytotoxicity and cell imaging studies in HeLa cells

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Supplementary files

Article information


Submitted
19 Nov 2015
Accepted
22 Jan 2016
First published
26 Jan 2016

RSC Adv., 2016,6, 14171-14177
Article type
Paper

Synthesis of luminescent squaramide monoesters: cytotoxicity and cell imaging studies in HeLa cells

V. Fernández-Moreira, J. V. Alegre-Requena, R. P. Herrera, I. Marzo and M. C. Gimeno, RSC Adv., 2016, 6, 14171 DOI: 10.1039/C5RA24521D

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