Issue 45, 2016, Issue in Progress
From the journal:

RSC Advances

Bifunctional thiourea catalyzed asymmetric Michael addition of anthrone to methyleneindolinones†

Huaili Zhao,a   Mingyan Xiao,a   Lubin Xu,a   Liang Wang*ab  and  Jian Xiao*ab  

* Corresponding authors

a College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao, China
E-mail: chemjianxiao@163.com

b Open Project Program of Hubei Key Laboratory of Drug Synthesis and Optimization, Jingchu University of Technology (Nos. OPP2015YB01 and OPP2015ZD02), China

Abstract

Biologically significant hybrid derivatives of oxindoles and anthrones were prepared in high yield, high regioselectivity and high stereoselectivity via bifunctional thiourea catalyzed asymmetric conjugate addition of anthrone to methyleneindolinones. The regioselectivity and stereoselectivity could be finely tuned via change of substituents in methyleneindolinones.

Graphical abstract: Bifunctional thiourea catalyzed asymmetric Michael addition of anthrone to methyleneindolinones

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Article information

DOI
https://doi.org/10.1039/C5RA21614A
Article type
Paper
Submitted
16 Oct 2015
Accepted
08 Apr 2016
First published
11 Apr 2016

RSC Adv., 2016,6, 38558-38562

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Bifunctional thiourea catalyzed asymmetric Michael addition of anthrone to methyleneindolinones

H. Zhao, M. Xiao, L. Xu, L. Wang and J. Xiao, RSC Adv., 2016, 6, 38558 DOI: 10.1039/C5RA21614A

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