Issue 1, 2016

Peroxide-free synthesis of benzo[b][1,4]thiazine 1,1-dioxides and their antimicrobial study

Abstract

A peroxide-free reaction protocol for the oxidation of benzo[b][1,4]thiazines has been developed under mild conditions. A library of benzo[b][1,4]thiazine 1,1-dioxide derivatives with broad functionalities have been synthesized in high yields. An in vitro antimicrobial study along with statistical analysis, MIC study and bacterial killing kinetics were investigated. The synthesized 1,4-benzothiazine sulfone derivatives possess strong antimicrobial activity against the reference strains.

Graphical abstract: Peroxide-free synthesis of benzo[b][1,4]thiazine 1,1-dioxides and their antimicrobial study

Supplementary files

Article information

Article type
Paper
Submitted
04 Oct 2015
Accepted
14 Dec 2015
First published
16 Dec 2015

RSC Adv., 2016,6, 201-207

Peroxide-free synthesis of benzo[b][1,4]thiazine 1,1-dioxides and their antimicrobial study

S. Mitra, S. Mukherjee and A. Hajra, RSC Adv., 2016, 6, 201 DOI: 10.1039/C5RA20541G

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