Textile/Al2O3–TiO2 nanocomposite as an antimicrobial and radical scavenger wound dressing

Abstract

Improving the antimicrobial activity and radical scavenging ability of a textile-based nanocomposite (textile/TiO₂, textile/Al₂O₃/TiO₂, textile/Al₂O₃ and textile/Al₂O₃–TiO₂ bimetal oxide nanocomposite) is the key issue in developing a good and flexible wound dressing. In this work, flexible textile attached with Al₂O₃–TiO₂ nanoparticles was prepared by dipping the textile in a suspension containing Al₂O₃–TiO₂ nanoparticles (150 mmol l⁻¹). The mean radical scavenging ability for textile/TiO₂, textile/Al₂O₃/TiO₂, textile/Al₂O₃ and textile/Al₂O₃–TiO₂ bimetal oxide nanocomposites as measured by liquid ultraviolet visible spectroscopy (UV-Vis) coupled with dependence formula was 0.2%, 35.5%, 35.0% and 38.2%, respectively. Based on the X-ray diffraction (XRD) patterns, the preface reactive oxygen species (ROS) scavenging ability shown by the textile/Al₂O₃–TiO₂ bimetal oxide nanocomposite is most probably caused by the crystal structure concluding in a corundum-like structure, with Al³⁺ ions filling the octahedral sites in the lattice. Increased antimicrobial activity measured by optical density at 600 nm recorded for textile/Al₂O₃–TiO₂ bimetal oxide nanocomposites showed better interaction between Al₂O₃ and TiO₂ nanoparticles. This good interaction is expected to lead to better antimicrobial and radical scavenging ability as shown by the E. coli and human skin fibroblast (HSF) cytotoxicity tests, respectively.