Jump to main content
Jump to site search

Issue 126, 2015
Previous Article Next Article

Preparation of luminescent titania/dye hybrid nanoparticles and their dissolution properties for controlling cellular environments

Author affiliations

Abstract

To design non-cytotoxic controlled release system is one of the major challenges in such a field as biomedicine. For this purpose, well-defined, luminescent and cytocompatible titania/dye hybrid nanoparticles (NPs) are synthesized. Hybrid NPs with a uniform size/shape are achieved through the precisely controlled microfluidic hydrolysis and co-condensation reactions of titanium tetraisopropoxide and 3-aminopropyltriethoxysilane in the presence of octadecylamine (ODA). By adding the cell-staining luminescent dye of fluorescein isothiocyanate (FITC) molecules to the starting solution, the spherical titania/aminopropyl-silica/ODA/FITC hybrid NPs (average diameter: 400 nm, coefficient of variation: 9.5%) are successfully prepared. Interestingly, the NPs demonstrate enhanced luminescence after treating them with phosphate buffered saline (PBS) and a possible mechanism is discussed. These NPs are not dispersed in PBS during the treatment due to their hydrophobic surface, which is an important feature to avoid cytotoxicity caused by an endocytic pathway. The NIH3T3 fibroblast viability test revealed that the hybrid NPs are not cytotoxic, realizing the clear imaging of the cellular shapes by the cellular gradual reactions mainly with the FITC released from the hybrid NPs floating at the interface. Therefore, the well-defined hybrid NPs with tailored surface/release properties are promising candidates for slowly-controlling cellular environmental systems (e.g., drug delivery systems).

Graphical abstract: Preparation of luminescent titania/dye hybrid nanoparticles and their dissolution properties for controlling cellular environments

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Nov 2015, accepted on 24 Nov 2015 and first published on 10 Dec 2015


Article type: Paper
DOI: 10.1039/C5RA23026H
RSC Adv., 2015,5, 104343-104353

  •   Request permissions

    Preparation of luminescent titania/dye hybrid nanoparticles and their dissolution properties for controlling cellular environments

    K. Shiba, M. Tagaya, T. Sugiyama and N. Hanagata, RSC Adv., 2015, 5, 104343
    DOI: 10.1039/C5RA23026H

Search articles by author

Spotlight

Advertisements