Jump to main content
Jump to site search

Issue 116, 2015
Previous Article Next Article

Electrochemical study of ivabradine hydrochloride ion selective electrodes using different ionophores

Author affiliations

Abstract

Three novel ivabradine hydrochloride (IH) selective electrodes were investigated with dioctylphthalate (DOP) as a plasticizer in a polymeric matrix of polyvinyl chloride (PVC). Sensor 1 was fabricated using tetrakis(4-chlorophenyl)borate (TpClPB) as an anionic exchanger without incorporation of an ionophore. Sensors 2 and 3 were constructed using 4-tertary butyl sulfocalix-8-arene and 2-hydroxypropyl β-cyclodextrin as an ionophore. Linear responses of IH within the concentration ranges of 10−5 to 10−2 mol L−1 were obtained using sensors 1, 2 and 3, respectively. Near Nernstian slopes of 56.39, 56.1.50 and 57.7 mV/decade over the pH range of 4–8 were observed. The selectivity coefficients of the developed sensors indicated excellent selectivity for IH. The proposed sensors displayed useful analytical characteristics for the determination of IH in bulk powder, pharmaceutical formulation and biological fluids (plasma, homogenized rat heart tissue).

Graphical abstract: Electrochemical study of ivabradine hydrochloride ion selective electrodes using different ionophores

Back to tab navigation

Publication details

The article was received on 10 Oct 2015, accepted on 30 Oct 2015 and first published on 06 Nov 2015


Article type: Paper
DOI: 10.1039/C5RA21033J
RSC Adv., 2015,5, 95592-95597

  •   Request permissions

    Electrochemical study of ivabradine hydrochloride ion selective electrodes using different ionophores

    N. F. Abo-Talib, M. H. Tammam and A. K. Attia, RSC Adv., 2015, 5, 95592
    DOI: 10.1039/C5RA21033J

Search articles by author

Spotlight

Advertisements