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Issue 115, 2015
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A two-step continuous flow synthesis of amides from alcohol using a metal-free catalyst

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Abstract

Metal-free oxidative amination of aromatic alcohols in the presence of TBHP provides convenient access to amides in 86–96% yield under mild reaction conditions within 15 min in a two-step continuous flow reactor system. This method avoids expensive transition metal catalysts and integrates alcohol oxidation and amide bond formation, which are usually accomplished separately, into a single operation.

Graphical abstract: A two-step continuous flow synthesis of amides from alcohol using a metal-free catalyst

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Publication details

The article was received on 08 Oct 2015, accepted on 29 Oct 2015 and first published on 30 Oct 2015


Article type: Paper
DOI: 10.1039/C5RA20838F
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Citation: RSC Adv., 2015,5, 95014-95019

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    A two-step continuous flow synthesis of amides from alcohol using a metal-free catalyst

    J. Gu, Z. Fang, C. Liu, Z. Yang, X. Li, P. Wei and K. Guo, RSC Adv., 2015, 5, 95014
    DOI: 10.1039/C5RA20838F

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