Issue 110, 2015
From the journal:

RSC Advances

Evolutionary identification of affinity peptides for the detection of sepsis biomarker procalcitonin†

J. P. Park,*a   C. Y. Park,a   A. Y. Parka  and  M. Y. Ryua  

* Corresponding authors

a Department of Pharmaceutical Engineering, Daegu Haany University, Gyeongsan 38610, Republic of Korea
E-mail: jppark@dhu.ac.kr
Fax: +82-53-819-1406

Abstract

We demonstrate for the first time the use of phage display for identification and selection of novel peptides that are capable of binding to procalcitonin. The best peptide specific for procalcitonin has an amino acid sequence of ‘MSCAGHMCTRFV’ and the binding affinity was observed with a nanomolar binding.

Graphical abstract: Evolutionary identification of affinity peptides for the detection of sepsis biomarker procalcitonin

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Article information

DOI
https://doi.org/10.1039/C5RA20260D
Article type
Communication
Submitted
30 Sep 2015
Accepted
16 Oct 2015
First published
16 Oct 2015

RSC Adv., 2015,5, 90531-90533

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Evolutionary identification of affinity peptides for the detection of sepsis biomarker procalcitonin

J. P. Park, C. Y. Park, A. Y. Park and M. Y. Ryu, RSC Adv., 2015, 5, 90531 DOI: 10.1039/C5RA20260D

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