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Issue 113, 2015

Mesoporous carbon/CuS nanocomposites for pH-dependent drug delivery and near-infrared chemo-photothermal therapy

Author affiliations

Abstract

Spurred by the recent development in nanotechnology, multi-functional therapeutic platforms have emerged as promising anti-cancer treatments for their combinational effects. In this paper, we report a novel drug delivery system composed of mesoporous carbon nanospheres (MCN) of 150 to 200 nm in diameter capped with copper sulfide (CuS) nanoparticles (NPs). MCNs can efficiently load doxorubicin (DOX, an anti-cancer drug) due to their hollow and porous structures as well as the π–π stacking interactions between MCN and DOX. DOX is retained in MCN under a basic and physiological environment, but releases rapidly under an acidic environment in its ionized state. Due to the intrinsic near-infrared (NIR) absorption and photothermal conversion ability of copper sulfide nanoparticles, heat is generated for killing tumor cells as well as stimulating DOX release upon NIR irradiation. Thus, this complex (MCN–CuS) exhibits efficient drug loading, low pre-release, temperature-, NIR- and pH-responsive DOX release, and combined antitumor activity.

Graphical abstract: Mesoporous carbon/CuS nanocomposites for pH-dependent drug delivery and near-infrared chemo-photothermal therapy

Article information


Submitted
21 Sep 2015
Accepted
21 Oct 2015
First published
26 Oct 2015

RSC Adv., 2015,5, 93226-93233
Article type
Paper
Author version available

Mesoporous carbon/CuS nanocomposites for pH-dependent drug delivery and near-infrared chemo-photothermal therapy

L. Zhang, Y. Li, Z. Jin, K. M. Chan and J. C. Yu, RSC Adv., 2015, 5, 93226 DOI: 10.1039/C5RA19458J

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