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Issue 113, 2015
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Novel bivalent spermine-based neutral neogalactolipids for modular gene delivery systems

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Abstract

New bivalent spermine-based neutral neogalactolipids have been synthesized to develop effective modular gene delivery systems (MGDS) targeting hepatocyte asialoglycoprotein receptors. MGDS composed of new neogalactolipids, cationic gemini-amphiphile, and DOPE were agglutinated in the presence of lectin RCA120 and provided efficient delivery of fluorescently-labeled oligodeoxyribonucleotides into HepG2 cells.

Graphical abstract: Novel bivalent spermine-based neutral neogalactolipids for modular gene delivery systems

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Supplementary files

Article information


Submitted
27 Aug 2015
Accepted
26 Oct 2015
First published
26 Oct 2015

RSC Adv., 2015,5, 93262-93266
Article type
Communication
Author version available

Novel bivalent spermine-based neutral neogalactolipids for modular gene delivery systems

E. A. Ivanova, A. V. Filatov, N. G. Morozova, M. A. Zenkova and M. A. Maslov, RSC Adv., 2015, 5, 93262 DOI: 10.1039/C5RA17389B

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