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Issue 108, 2015
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Water-soluble Zn–Ag–In–Se quantum dots with bright and widely tunable emission for biomedical optical imaging

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Abstract

Quantum dots (QDs), as a new fluorescent reagent, should have potential applications in biomedical optical imaging; however their biological applications are limited by the toxicity of the component elements. Hence, in this work, water-soluble Zn–Ag–In–Se (ZAISe) QDs were synthesized without using highly toxic heavy metal elements. The as-prepared quaternary QDs exhibit bright and widely composition-tunable photoluminescence (PL) emission (namely, maximum PL quantum yield (QY) reaching 30%; PL peak from 450 to 760 nm). MTT assay proved that these QDs have much less cytotoxicity than Cd-based QDs. After being further modified by DHLA–PEG–Suc–RGD ligands, water-soluble ZAISe QDs were explored as a fluorescent probe for tumor cell-targeted optical imaging. In vitro and in vivo results demonstrate that ZAISe QDs prepared here should be a promising substitute for Cd-based QDs in biomedical optical imaging.

Graphical abstract: Water-soluble Zn–Ag–In–Se quantum dots with bright and widely tunable emission for biomedical optical imaging

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Publication details

The article was received on 23 Aug 2015, accepted on 12 Oct 2015 and first published on 13 Oct 2015


Article type: Paper
DOI: 10.1039/C5RA17046J
RSC Adv., 2015,5, 88583-88589

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    Water-soluble Zn–Ag–In–Se quantum dots with bright and widely tunable emission for biomedical optical imaging

    J. Wang, R. Zhang, F. Bao, Z. Han, Y. Gu and D. Deng, RSC Adv., 2015, 5, 88583
    DOI: 10.1039/C5RA17046J

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