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Issue 99, 2015
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Synthetic approaches and functionalizations of imidazo[1,2-a]pyrimidines: an overview of the decade

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Abstract

Imidazo[1,2-a]pyrimidine has been receiving significant attention in the synthetic chemistry community through different chemosynthetic methodologies viz., multicomponent reactions, condensation reactions, intramolecular cyclizations, tandem reaction, carbon–hydrogen, carbon–carbon, carbon–nitrogen bond formation, aza-Michael–Mannich reaction, chiral compounds synthesis etc. The mechanisms for the selected reactions are also discussed to observe the formation of this heterocyclic moiety. This review comprehensively summarizes the recently reported various synthetic approaches along with its functionalization at 3-positions to construct this privileged scaffold for further use in the development of new chemosynthetic strategies and drug development due to its wide range of applications in medicinal chemistry.

Graphical abstract: Synthetic approaches and functionalizations of imidazo[1,2-a]pyrimidines: an overview of the decade

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Article information


Submitted
26 Jul 2015
Accepted
15 Sep 2015
First published
15 Sep 2015

RSC Adv., 2015,5, 81608-81637
Article type
Review Article

Synthetic approaches and functionalizations of imidazo[1,2-a]pyrimidines: an overview of the decade

R. Goel, V. Luxami and K. Paul, RSC Adv., 2015, 5, 81608
DOI: 10.1039/C5RA14795F

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