Issue 83, 2015

Synthesis of functionalized benzoxazines by copper-catalyzed C(sp3)–H bond functionalization of acetonitrile with olefinic amides

Abstract

A copper-mediated oxycyanomethylation reaction of olefinic amides with acetonitrile was developed for the synthesis of important benzoxazine derivatives. The reactions involve the activation of the C(sp3)–H bond of acetonitrile and radical cyclization processes for the construction of new C–C and C–O bonds.

Graphical abstract: Synthesis of functionalized benzoxazines by copper-catalyzed C(sp3)–H bond functionalization of acetonitrile with olefinic amides

Supplementary files

Article information

Article type
Communication
Submitted
14 Jul 2015
Accepted
30 Jul 2015
First published
03 Aug 2015

RSC Adv., 2015,5, 67829-67832

Synthesis of functionalized benzoxazines by copper-catalyzed C(sp3)–H bond functionalization of acetonitrile with olefinic amides

X. Chu, X. Xu, H. Meng and S. Ji, RSC Adv., 2015, 5, 67829 DOI: 10.1039/C5RA14729H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements