Issue 108, 2015

Folic acid-conjugated BSA nanocapsule (n-BSA–FA) for cancer targeted radiotherapy and imaging

Abstract

New carrier systems have generated new opportunities to deliver drugs to specific targets. Capitalizing on recent achievements in the area of nanotechnology and nuclear medicine, we sought to develop a radiolabeled nano-drug that could accumulate in tumors via tumor-selective targeted delivery system and could treat the tumors with radionuclide. 125/131I-labeled nano-drug, [125/131I]I–n-BSA–FA, was prepared in this paper, with high radiochemical yield and long stability in vitro. Pharmacokinetics and biodistribution studies, as well as SPECT/CT imaging of the radiolabeled nanoparticles, [125I]I–n-BSA–FA, were performed on a mouse model of breast cancer. Accumulation of this drug in tumor peaked at 24 h after injection and was measured to be 11.3 percentage injected dose per gram (ID% per g). In addition, a therapeutic study was performed to evaluate the therapeutic effect of [131I]I–n-BSA–FA. It completely retarded the tumor growth with only one injection. The nano-carrier drugs described here targeted malignant tumors and may be useful for both tumor imaging and tumor treatment combined in clinic.

Graphical abstract: Folic acid-conjugated BSA nanocapsule (n-BSA–FA) for cancer targeted radiotherapy and imaging

Article information

Article type
Paper
Submitted
02 Jul 2015
Accepted
12 Oct 2015
First published
12 Oct 2015

RSC Adv., 2015,5, 88560-88566

Author version available

Folic acid-conjugated BSA nanocapsule (n-BSA–FA) for cancer targeted radiotherapy and imaging

S. Liang, X. Jin, Y. Ma, J. Guo and H. Wang, RSC Adv., 2015, 5, 88560 DOI: 10.1039/C5RA12804H

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