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Issue 76, 2015
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‘Aggregation induced phosphorescence’ active iridium(iii) complexes for integrated sensing and inhibition of bacterial growth in aqueous solution

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Abstract

The present study attempts to develop a sensitive method to utilize ‘aggregation induced phosphorescence (AIP)’ active iridium(III) complexes as potential agents for “integrated” sensing and inhibition of bacterial growth in aqueous systems. The utilization of iridium(III) complexes for microbial detection in bodies of water has been demonstrated using Escherichia coli (E. coli) as a representative bacterial strain. The tested iridium(III) complexes also exhibited antibacterial properties against representative Gram positive and Gram negative bacterial strains with minimum inhibitory concentration (MIC) values of 4 and 8 μg mL−1, respectively. Microscopic observations indicated that these complexes could penetrate into the bacterial cells and result in subsequent cell death. Preliminary mechanistic studies showed that the DNA binding ability of the iridium(III) complexes is responsible for their antibacterial properties. The observed “dual” role in detection as well as inhibition of bacterial growth makes this study highly promising and encouraging for the exploration of the applicability of other less expensive metal complexes for monitoring and controlling the bacterial levels in drinking and sea water systems at a commercial level.

Graphical abstract: ‘Aggregation induced phosphorescence’ active iridium(iii) complexes for integrated sensing and inhibition of bacterial growth in aqueous solution

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Article information


Submitted
29 May 2015
Accepted
07 Jul 2015
First published
08 Jul 2015

RSC Adv., 2015,5, 61983-61988
Article type
Paper
Author version available

‘Aggregation induced phosphorescence’ active iridium(III) complexes for integrated sensing and inhibition of bacterial growth in aqueous solution

N. Jain, P. Alam, I. R. Laskar and J. Panwar, RSC Adv., 2015, 5, 61983
DOI: 10.1039/C5RA10161A

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