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Issue 78, 2015
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Bi-modal cancer treatment utilizing therapeutic ultrasound and an engineered therapeutic nanobubble

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Abstract

Herein we report a bi-modal cancer treatment technique using therapeutic ultrasound in the presence of a novel sorafenib loaded nanobubble for hepatocellular carcinoma. Therapeutic ultrasound was used for improving fusion-triggered drug release from nanobubbles leading to enhanced cytotoxicity in HepG2 cells by greater than two folds improvement in IC50 values. This strategy could also be made compatible with catheter-based devices to derive a highly localized treatment approach, a concept that might be extendable to metastatic cancers as well.

Graphical abstract: Bi-modal cancer treatment utilizing therapeutic ultrasound and an engineered therapeutic nanobubble

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Article information


Submitted
13 May 2015
Accepted
20 Jul 2015
First published
20 Jul 2015

RSC Adv., 2015,5, 63839-63845
Article type
Paper
Author version available

Bi-modal cancer treatment utilizing therapeutic ultrasound and an engineered therapeutic nanobubble

S. K. Misra, G. Ghoshal, T. W. Jensen, P. S. Ray, E. C. Burdette and D. Pan, RSC Adv., 2015, 5, 63839 DOI: 10.1039/C5RA08977H

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