Issue 76, 2015
From the journal:

RSC Advances

Dual role of pinostrobin-a flavonoid nutraceutical as an efflux pump inhibitor and antibiofilm agent to mitigate food borne pathogens†

Lowrence Rene Christena,‡a   Shankar Subramaniam,‡a   Mohan Vidhyalakshmi,a   Vijayalakshmi Mahadevan,a   Aravind Sivasubramanian ORCID logo §*a  and  Saisubramanian Nagarajan ORCID logo §*ab  

* Corresponding authors

a School of Chemical and Biotechnology, SASTRA University, Thanjavur 613 401, India
E-mail: sai@scbt.sastra.edu, arvi@biotech.sastra.edu

b Center for Research on Infectious Diseases, SCBT, SASTRA University, Thanjavur 613 401, India

Abstract

Nutraceutical pinostrobin displayed synergy with ciprofloxacin against diverse bacteria causing drastic 128 fold reduction in ciprofloxacin MIC in MRSA and significant antibiofilm effect against E. coli and P. aeruginosa at subinhibitory concentrations. Studies with NorA mutants of S.aureus revealed efflux inhibition of pinostrobin is mediated by efflux pumps other than NorA.

Graphical abstract: Dual role of pinostrobin-a flavonoid nutraceutical as an efflux pump inhibitor and antibiofilm agent to mitigate food borne pathogens

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Article information

DOI
https://doi.org/10.1039/C5RA07165H
Article type
Communication
Submitted
20 Apr 2015
Accepted
08 Jul 2015
First published
13 Jul 2015

RSC Adv., 2015,5, 61881-61887

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Dual role of pinostrobin-a flavonoid nutraceutical as an efflux pump inhibitor and antibiofilm agent to mitigate food borne pathogens

L. R. Christena, S. Subramaniam, M. Vidhyalakshmi, V. Mahadevan, A. Sivasubramanian and S. Nagarajan, RSC Adv., 2015, 5, 61881 DOI: 10.1039/C5RA07165H

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